Essential oil analysis and antibacterial activity of Ferula assa-foetida L. aerial parts from Neishabour mountains

Document Type : Original paper

Authors

1 Department of Drug and Food Control, Faculty of Pharmacy and Pharmaceutical Quality Assurance Research Center, Tehran University of Medical Sciences, Tehran 14155-6451, Iran.

2 Department of Pharmacognosy and Biotechnology, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran.

3 Pharmaceutical Sciences Branch, Islamic Azad University, Tehran 19419-33111, Iran.

4 Department of Drug and Food Control, Faculty of Pharmacy and Biotechnology Research Center, Tehran University of Medical Sciences, Tehran 14155-6451, Iran.

5 Food and Drug Organization, Ministry of Health and Medical Education of Iran & Department of Traditional Pharmacy, Faculty of Traditional Medicine, Tehran University of Medical Sciences, Tehran, Iran.

6 Department of Pharmacognosy, Faculty of Pharmacy and Persian Medicine and Pharmacy Research Center, Tehran University of Medical Sciences, Tehran14155-6451, Iran.

7 Faculty of Land and Food Systems, University of British Columbia, Vancouver, BC, Canada.

8 Department of Pharmacognosy, Faculty of Pharmacy and Persian Medicine and Pharmacy Research Center, Tehran University of Medical Sciences, Tehran14155-6451, Iran. Faculty of Land and Food Systems, University of British Columbia, Vancouver, BC, Canada.

Abstract

Background and objectives: Ferula assa-foetida (asafoetida) is a native Iranian species which grows in different regions and climates in Iran. The plant is well known in Iranian Traditional Medicine as well as folk medicine for treatment of diseases. Several studies have been carried out on the essential oil of this species collected from different areas of Iran. This study is the first report about the essential oil of the plant collected from Neishabour mountains that is a potent area for growing this valuable plant species.
Methods: Essential oil of the aerial part of Ferula assa-foetidawhich wascollected from Neishabour, Iran, was analyzed by gas chromatography-mass spectroscopy (GC/MS). The minimum inhibitory concentrations of the essential oil was investigated against both Gram-positive (Staphylococcus epidermidis, Staphylococcus aureus, Bacillus subtilis) and Gram-negative (Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumonia) bacteria using microdilution method.
Results: Twenty three components representing 97.06% of the total oil were identified. (E)-1-propenyl sec-butyl disulfide (53.77%), (Z)-1-propenyl sec-butyl disulfide (35.6%) and α-pinene (3.4%) were identified as major components. The MICof the essential oil ranged from 12-24 mg/mL against all tested bacteria.
Conclusion: The results indicated that among various compounds identified in the essential oil of F. assa-foetida L. from Neishabour mountains, disulphide compounds were the major constituents of the oil. In comparison to other reports of this plant around the country, disulphide compounds could be the reason of its moderate antibacterial effect.

Keywords

References

[1] Mozaffarian V. A dictionary of Iranian plant names. Tehran: Farhang Mo'aser, 1996.
[2] Sahebkar A. Biological activities of essential oils from the genus Ferula (Apiaceae). Asian Biomed. 2010; 4(6): 835-847.
[3] Bamoniri A, Mazoochi A. Determination of bioactive and fragrant molecules from leaves and fruits of Ferula assa-foetida L. growing in central Iran by nanoscal injection. Dig J Nanomater Biostruct. 2009; 4(2): 323-328.
[4] El-Razek MHA, Ohta S, Ahmed AA, Hirata T. Sesquiterpene coumarins from the roots of Ferula assa-foetida. Phytochemistry. 2001; 58(8): 1289-1295.
[5] Valencia E, Feria M, Díaz JG, González A, Bermejo J. Antinociceptive, anti-inflammatory and antipyretic effects of lapidin, a bicyclic sesquiterpene. Planta Med. 1994; 60(5): 395-399.
[6] Singh M, Agnihotri A, Garg S, Agarwal S, Gupta D, Keshri G, Kamboj VP. Antifertility and hormonal properties of certain carotane sesquiterpenes of Ferula jaeschkeana. Planta Med. 1988; 54(6): 492-494.
[7] Prakash AO, Pathak S, Mathur R. Postcoital contraceptive action in rats of a hexane extract of the aerial parts of Ferula jaeschkeana. J Ethnopharmacol. 1991; 34(2): 221-234.
[8] Aqel M, Al-Khalil S, Afifi F. Effects of a Ferula sinaica root extract on the uterine smooth muscle of rat and guinea pig. J Ethnopharmacol. 1991; 31(3): 291-297.
[9] Zargari A. Medicinal plants. Tehran: Tehran University Publications, 1996.
[10] Iranshahy M, Iranshahi M. Traditional uses, phytochemistry and pharmacology of asafoetida (Ferula assa-foetida oleo-gum-resin)-A review. J Ethnopharmacol. 2011; 134(1): 1-11.
[11] Abedi D, Jalali M, Sadeghi N. Composition and antimicrobial activity of oleo-gum-resin of Ferula gumosa Bioss. essential oil using Alamar Blue. Res Pharm Sci. 2009; 3(1): 41-45.
[12] Khajeh M, Yamini Y, Bahramifar N, Sefidkon F, Pirmoradei MR. Comparison of essential oils compositions of Ferula assa-foetida obtained by supercritical carbon dioxide extraction and hydrodistillation methods. Food Chem. 2005; 91(4): 639-644.
[13] Sadraei H, Ghannadi A, Malekshahi K. Composition of the essential oil of asa-foetida and its spasmolytic action. Saudi Pharm J. 2003; 11(3): 136-140.
[14] Rahman MU, Gul S, Odhano EA. Antimicrobial activities of Ferula assa-foetida oil against Gram-positive and Gram-negative bacteria. American-Eurasian J Agric Environ. 2008; 4(2): 203-206.
[15] Kunwar PS, Sharma M, Bhat G, Pandey M, Sharma V. Antimicrobial activity  of essential oil of Ferula asafoetida (HINGE). Pharmacie Globale. 2010; 1(2): 1-3.
[16] Khosravi Dehaghi N, Ostad SN, Maafi N, Pedram S, Ajani Y, Hadjiakhoondi A, Khanavi M. Cytotoxic activity of the essential oil of Salvia verticillata L. Res J Pharmacogn. 2014; 1(3): 27-33.
[17] Masada Y. Analysis of essential oils by gas chromatography and mass spectrometry. New York: John Wiley & Sons, 1976.
[18] Adams RP. Identification of essential oil components by gas chromatography/mass spectrometry. 4th ed. Illinois: Allured publishing , 2007.
[19] Vahidi H, Kamalinejad M, Sedaghati N. Antimicrobial properties of Croccus sativus L. Iran J Pharm Res. 2002; 1(1): 33-35.
[20] Manayi A, Saeidnia S, Shekarchi M, Hadjiakhoondi A, Shams Ardekani MR, Khanavi M. Comparative study of the essential oil and hydrolate composition of Lythrum salicaria L. obtained by hydro-distillation and microwave distillation methods. Res J Pharmacogn. 2014; 1(2): 33-38.
[21] Ericsson HM, Sherris JC. Antibiotic sensitivity testing. Report of an international collaborative study. Acta Pathol Microbiol Scand B Microbiol Immunol. 1971; 217:S 217: 1.
[22] Vazirian M, Alehabib S, Jamalifar H,  Fazeli MR, Najarian Toosi A, Khanavi M. Antimicrobial effect of cinnamon (Cinnamomum verum J. Presl) bark essential oil in cream-filled cakes and pastries. Res J Pharmacogn. 2015; 2(4): 11-16.
[23] Alipour Z, Taheri P, Samadi N. Chemical composition and antibacterial activity of the essential oils from flower, leaf and stem of Ferula cupularis growing wild in Iran. Pharm Biol. 2015; 53(4): 483-487.
[24] Mirzaei HH, Hasanloo T. Essential oil composition of root of Ferula assa-foetida from two Iranian localities (Gonabad and Tabas). Asian J Chem. 2009; 21(8): 6354-6358.
[25] Kanani MR, Rahiminejad MR, Sonboli A, Mozaffarian V, Kazempour Osaloo S, Nejad Ebrahimi S. Chemotaxonomic significance of the essential oils of 18 Ferula species (Apiaceae) from Iran. Chem biodivers. 2011; 8(3): 503-517.
[26] Kameli Z, Alizadeh A, Aboutalebi A. Bitter and Sweet Ferula assa-foetida L. essential oil composition from Iran and its comparison with Ferula assa-foetida L. used in India. Intl Res J Appl Basic Sci. 2012; 3(5): 919-923.
[27] Ahmadvand H, Amiri H, Elmi ZD, Bagheri S. Chemical composition and antioxidant properties of Ferula-assa-foetida leaves essential oil. Iranian J Pharmacol Ther. 2013; 12(2): 52-57.
[28] Bahrami G, Soltani R, Sajjadi SE, Kanani MR, Naderi R, Ghiasvand N, Shokoohinia Y. Essential oil composition of Ferula assa-foetida L. fruits from western Iran. J Rep Pharm Sci. 2013; 2(2): 90-97.
[29] Kavoosi G, Rowshan V. Chemical composition, antioxidant and antimicrobial activities of essential oil obtained from Ferula assa-foetida oleo-gum-resin: effect of collection time. Food Chem. 2013; 138(4): 2180-2187.
[30] Hadavand Mirzaei H, Hasanloo T. Assessment of chemical composition of essential oil of Ferula assa-foetida oleo-gum-resin from two different sites of Yazd province in center of Iran. Res J Pharmacogn. 2014; 1(2): 51-54.
[31] Dehpour AA, Ebrahimzadeh MA, Seyed Fazel N, Seyed Mohammad N. Antioxidant activity of the methanol extract of Ferula assa-foetida and its essential oil composition. Grasas aceites. 2009; 60(4): 405-412.
[32] Iranshahi M, Hassanzadeh-Khayat M, Bazzaz BSF, Sabeti Z, Enayati F. High content of polysulphides in the volatile oil of Ferula latisecta Rech. F. et Aell. fruits and antimicrobial activity of the oil. J Essent Oil Res. 2008; 20(2): 183-185.
[33] Kim S, Kubec R, Musah RA. Antibacterial and antifungal activity of sulfur-containing compounds from Petiveria alliacea L. J Ethnopharmacol. 2006; 104(1): 188-192.

Files

Share

How to cite

Statistics