[1] Mousavi SZ, Bathaie SZ. Historical uses of saffron: identifying potential new avenues for modern research. Avicenna J Phytomed. 2011; 1(2): 57-66.
[2] Hosseinzadeh H. Saffron: a herbal medicine of third millennium. Jundishapur J Nat Pharm Prod. 2014; 9(1): 1-2.
[3] Akhondzadeh S, Sabet MS, Harirchian M, Togha M, Cheraghmakani H, Razeghi S, Hejazi SSh, Yousefi MH, Alimardani R, Jamshidi A, Zare F, Moradi A. Saffron in the treatment of patients with mild to moderate Alzheimer’s disease: a 16‐week, randomized and placebo‐controlled trial. J Clin Pharm Ther. 2010; 35(5): 581-588.
[4] Kamalipour M, Akhondzadeh S. Cardiovascular effects of saffron: an evidence-based review. J Tehran Heart Cent. 2011; 6(2): 59-61.
[5] Rao SV, Muralidhara, Yenisetti SC, Rajini PS. Evidence of neuroprotective effects of saffron and crocin in a Drosophila model of Parkinsonism. Neurotoxicology. 2016; 52: 230-242.
[6] Skladnev NV, Johnstone DM. Neuroprotective properties of dietary saffron: more than just a chemical scavenger? Neural Regen Res. 2017; 12(2): 210-211.
[7] Azari H, Ebrahimi S, Saeb S, Ghanbari A, Peyravian F, Mokarram P. The Effect of saffron aquatic extract and crocin on the differentiation of neural stem cells into oligodendrocyte precursor cells. Shiraz EMed J. 2018; 19(3): 1-7.
[8] Sadeghnia HR, Shaterzadeh H, Forouzanfar F, Hosseinzadeh H. Neuroprotective effect of safranal, an active ingredient of Crocus sativus, in a rat model of transient cerebral ischemia. Folia Neuropathol. 2017; 55(3): 206-213.
[9] Bisti S, Maccarone R, Falsini B. Saffron and retina: neuroprotection and pharmacokinetics. Vis Neurosci. 2014; 31(4-5): 355-361.
[10] Amin A, Hamza AA, Bajbouj K, Ashraf SS, Daoud S. Saffron: a potential candidate for a novel anticancer drug against hepatocellular carcinoma. Hepatology. 2011; 54(3): 857-867.
[11] Hoshyar R, Mollaei H. A comprehensive review on anticancer mechanisms of the main carotenoid of saffron, crocin. J Pharm Pharmacol. 2017; 69(11): 1419-1427.
[12] Sun X, Vilar S, Tatonetti NP. High-throughput methods for combinatorial drug discovery. Sci Transl Med. 2013; Article ID 24089409.
[13] Ovesná J, Slabý O, Toussaint O, Kodíček M, Maršík P, Pouchová V, Vanĕk T. High throughput ‘omics’ approaches to assess the effects of phytochemicals in human health studies. Br J Nutr. 2008; 99(ES1): 127-134.
[14] Wheelock CE, Goss VM, Balgoma D, Nicholas B, Brandsma J, Skipp PJ, Snowden S, Burg D, D'Amico A, Horvath I, Chaiboonchoe A, Ahmed H, Ballereau S, Rossios C, Chung KF, Montuschi P, Fowler SJ, Adcock IM, Postle AD, Dahlén SE, Rowe A, Sterk PJ, Auffray C, Djukanovic R. Application of’omics technologies to biomarker discovery in inflammatory lung diseases. Eur Respir J. 2013; 42(3): 802-825.
[15] Baxevanis AD, Bader G, Wishart D. Bioinformatics: John Wiley & Sons, 2020.
[16] Perroud B, Lee J, Valkova N, Dhirapong A, Lin PY, Fiehn O, Kültz D, Weiss RH. Pathway analysis of kidney cancer using proteomics and metabolic profiling. Mol Cancer. 2006; 5(1): 1-17.
[17] Helleman J, Smid M, Jansen MP, Vander Burg ME, Berns EM. Pathway analysis of gene lists associated with platinum-based chemotherapy resistance in ovarian cancer: the big picture. Gynecol Oncol. 2010; 117(2): 170-176.
[18] Jack XY, Sieuwerts AM, Zhang Y, Martens JW, Smid M, Klijn JG, Wang Y, Foekens JA. Pathway analysis of gene signatures predicting metastasis of node-negative primary breast cancer. BMC Cancer. 2007; 7(1): 1-14.
[19] Zali H, Rezaei-Tavirani M, Vafaee R, Rezaei-Tavirani M. Gastric cardia adenocarcinoma pathway analysis. Gastroenterol Hepatol Bed Bench. 2013; 6(S1): 11-18.
[20] Tavirani MR, Tavirani SR, Rostami FT. Biochemical pathway analysis of gastric atrophy. Gastroenterol Hepatol Bed Bench. 2018; 11(2): 118-124.
[21] Rostami-Nejad M, Rezaei-Tavirani M, Zadeh-Esmaeel MM, RezaeiTavirani S, Akbari Z, Esmaeili S, Okhovatian F. Assessment of cytokine-mediated signaling pathway dysregulation in arm skin after CO2 laser therapy. J Lasers Med Sci. 2019; 10(4): 1-7.
[22] Natoli R, Zhu Y, Valter K, Bisti S, Eells J, Stone J. Gene and noncoding RNA regulation underlying photoreceptor protection: microarray study of dietary antioxidant saffron and photobiomodulation in rat retina. Molecular Vis. 2010; 16: 1801-1822.
[23] Mlecnik B, Galon J, Bindea G. Automated exploration of gene ontology term and pathway networks with ClueGO-REST. Bioinformatics. 2019; 35(19): 3864-3866.
[24] KEGG: Kyoto Encyclopedia of Genes and Genomes. [Accessed 2020]. Available from https://www.genome.jp/kegg/
[25] Bindea G, Galon J, Mlecnik B. CluePedia Cytoscape plugin: pathway insights using integrated experimental and in silico data. Bioinformatics. 2013; 29(5): 661-663.
[26] Khatri P, Sirota M, Butte AJ. Ten years of pathway analysis: current approaches and outstanding challenges. PLoS Comput Biol. 2012; 8(2): 1-10.
[27] Papin JA, Stelling J, Price ND, Klamt S, Schuster S, Palsson BO. Comparison of network-based pathway analysis methods. Trends Biotechnol. 2004; 22(8): 400-405.
[28] Piccardi M, Marangoni D, Minnella AM, Savastano MC, Valentini P, Ambrosio L, Capoluongo E, Maccarone R, Bisti S, Falsini B. A longitudinal follow-up study of saffron supplementation in early age-related macular degeneration: sustained benefits to central retinal function. Evid Based Complement Altern Med. 2012; Article ID 429124.
[29] Bajbouj K, Schulze-Luehrmann J, Diermeier S, Amin A, Schneider-Stock R. The anticancer effect of saffron in two p53 isogenic colorectal cancer cell lines. BMC Complement Altern Med. 2012; 12(1): 1-9.
[30] Kangas A, Nicholson DW, HoÈlttaÈ E. Involvement of CPP32/Caspase-3 in c-Myc-induced apoptosis. Oncogene. 1998; 16(3): 387-398.
[31] Keller U, Huber J, Nilsson JA, Fallahi M, Hall MA, Peschel C, Cleveland JL. Myc suppression of Nfkb2 accelerates lymphomagenesis. BMC Cancer. 2010; 10 :1-10.
[32] McHale CM, Zhang L, Lan Q, Li G, Hubbard AE, Forrest MS, Vermeulen R, Chen J, Shen M, Rappaport SM, Yin S, Smith MT, Rothman N. Changes in the peripheral blood transcriptome associated with occupational benzene exposure identified by cross-comparison on two microarray platforms. Genomics. 2009; 93(4): 343-349.
[33] Kim EK, Choi EJ. Pathological roles of MAPK signaling pathways in human diseases. Biochim Biophys Acta. 2010; 1802(4): 396-405.
[34] Lowe SW, Lin AW. Apoptosis in cancer. Carcinogenesis. 2000; 21(3): 485-495.
[35] Carson DA, Ribeiro JM. Apoptosis and disease. Lancet. 1993; 341(8855): 1251-1254.
[36] Mattson MP. Apoptosis in neurodegenerative disorders. Nat Rev Mol Cell Biol. 2000; 1(2): 120-130.